LIfe Extension Foundation
Home History Mission Accomplishments Funding Tax Information
LEF Accomplishments: CoQ10, Green Tea, DHEA
Page: 1 | 2 | 3 | 4

LEF Accomplishments


  • In 2013, Life Extension reported on the first enzyme formulation that facilitates digestion of dietary protein, fiber, and fat — without promoting the breakdown of starches and the rapid absorption of glucose into the bloodstream that triggers postprandial glucose surges.
  • In 2013, Life Extension researchers analyzed 12 independent studies that evaluated blood glucose levels and breast cancer risk and found that 9 of the studies revealed a correlation between higher fasting glucose, or other indicators of poor glycemic control, and increased risk of cancer.
  • In 2013, to enhance the body’s absorption of astaxanthin, Life Extension formulated this antioxidant carotenoid with phospholipids, clinically shown to boost astaxanthin absorption several-fold.
  • In 2013, Life Extension reported on a formula utilizing the digestive enzyme transglucosidase, which is scientifically shown to transform starches into prebiotic fiber in the digestive tract, helping to support healthy glucose and insulin levels.
  • In 2013, Life Extension published the updated, 5th edition of its Disease Prevention and Treatment book, containing more than 1,400 pages of innovative approaches to 130 common health concerns.
  • In 2013, to support both cognitive and circulatory function as well as the brain’s normal defenses and regenerative mechanisms, Life Extension reported on polyphenol gastrodin, an innovative compound that acts as a broad-spectrum “brain shield,” calming brain cells and protecting them from oxidant, inflammatory, and excitatory damage.
  • In 2013, Life Extension reported on the extracts of mung bean seed coat and EGCG (the major beneficial component in green tea), both powerful inhibitors of HMGB-1, the molecule that induces chronic inflammation, a chief accelerator of aging.
  • In 2013, Life Extension reported that a broad-spectrum glucose control supplement featuring white mulberry leaf extract, sorghum extract, and phloridzin, three natural ingredients which work on numerous key mechanisms to improve insulin sensitivity, reduce blood glucose levels, safely transport glucose out of the body, and reduce the creation of new glucose in the liver.
  • In 2013, Life Extension reported on a supplement containing omega-7 (palmitoleic acid), which has been shown to exert beneficial effects on many pathological components of metabolic syndrome. In addition to improving insulin sensitivity, lowering LDL-cholesterol-triglycerides, raising beneficial HDL, and helping to manage body weight, omega-7, most importantly, inhibits inflammation.
  • In 2013, in an unprecedented breakthrough, Life Extension published the first protocol validated to extend median survival in glioblastoma (brain tumor) patients to 4.7 years, whereas conventional therapies only provide survival time of 12-15 months.


  • In 2014, Life Extension identified a cause (leukoaraiosis) of cognitive decline that affects 60% of people late middle aged and older and developed protocols to slow its progress or prevent it entirely.
  • In 2014, Life Extension published a meticulous rebuttal to a flawed study that claimed that testosterone replacement increased risk of death from cardiovascular disease in men.
  • In 2014, to remind the public about the horrific persecutions endured by visionaries of the past, Life Extension published a historic account of innovations brutally suppressed by whatever “authority” existed at the time.
  • In 2014, to fill a funding gap caused by federal budget cuts, Life Extension Foundation stepped in to support a record number of scientists developing therapies to slow aging and cure cancer.
  • In 2014, Life Extension published a hypothesis by a world renowned expert that autism may be caused by a vitamin D deficit.
  • In 2014, to suppress pro-inflammatory cytokines at the root of most age-related diseases, Life Extension identified a novel plant extract (mung bean seed coat).
  • In 2014, zeroing in on an underlying cause of Alzheimer’s disease and stroke, Life Extension enlightened consumers to the brain damaging effects of “hypoperfusion” and identified validated methods to protect against it.
  • In 2014, to further document the lethal impact of excess glucose, Life Extension published a compendium of published studies showing increased risks of cancer, atherosclerosis, dementia, obesity, and accelerated aging in response to modestly elevated blood sugar levels.
  • In 2014, Life Extension published an exclusive report on the European Congress on Biogerontology, where an international group of scientists presented cutting-edge research on longevity epigenetics, rejuvenation of the immune system, the dangers of CMV infection, and calorie restriction.
  • In 2014, to expose a fatally flawed study published in the New England Journal of Medicine, Life Extension published a meticulous rebuttal showing the dangers of overdosing men on an estrogen-suppressing drug.
  • In 2014, to spare the lives of newly diagnosed cancer patients, Life Extension provided strong data to persuade oncologists to prescribe immune boosting drugs before surgery, radiation and chemotherapy is administered.
  • In 2014, an exclusive investigative report by Life Extension uncovered a generic drug rip-off where a topical cream (acyclovir) whose active ingredients cost 8 pennies was being sold to pharmacies for $600.
  • In 2014, to warn women facing hysterectomies, Life Extension urged that a common surgical procedure (morcellation) be avoided.   
  • In 2014, Life Extension presented case histories of terminal cancer patients who have been cured or put into long-term remission utilizing innovative, individualized treatment protocols.
  • In 2014, Life Extension revealed the importance of administering the proper form and dose of zinc lozenge to protect against the cold virus and outlined the 30-year journey that transpired before this zinc lozenge gained mainstream acceptance as a viable common cold treatment.
  • In 2014, Life Extension presented a clinical study on the pharmacokinetics of ursolic acid at the prestigious Experimental Biology Conference, held in San Diego, California.
  • In 2014, Life Extension reported on FBCx™ alpha-cyclodextrin, a patented super-fiber that absorbs fat molecules from food before they enter the bloodstream. This soluble fiber absorbs nine times its weight in dietary fat, without undesirable gastrointestinal side effects. Research shows that alpha-cyclodextrin selectively binds to unhealthy saturated and trans fats while maintaining healthy fats such as omega-3 fatty acids.
  • In 2014, the Life Extension Foundation sponsored a clinical study in which daily 7,000-IU doses of vitamin D improved several immunological parameters in HIV-positive children and young adults.
  • In 2014, a study sponsored by the Life Extension Foundation showed that epigallocatechin-3-gallate, a green tea derivative, improved cognitive function in young adults with Down syndrome.
  • In 2014, research funded by the Life Extension Foundation was published in the journal Nucleic Acids Research. This research, under Dr. Victoria Belancio, established that melatonin suppresses DNA (genome) instability, thereby protecting against cancer. The paper established that melatonin supplementation can be protective, and that shift-workers can be more vulnerable to DNA instability.
  • Life Extension Foundation provided funding for a review article authored, primarily, by Drs. Vera Gorbunova and Andrei Seluanov in which the genetics of remarkable longevity and cancer resistance observed in some rodents was explored. The article was published as the cover story in the August 2014 issue of Nature Review: Genetics, the leading scientific journal on the subject of heredity and genetics.
  • In 2014, Life Extension researchers developed an innovative, dual-mechanism formula designed to combat immune senescence. This formula is composed of two botanical compounds, Cistanche tubulosa extract and Reishi mushroom extract, that support adaptive (e.g., T cells and B cells) and innate (e.g., macrophages and neutrophils) immune response cells, respectively.
  • In 2014, Life Extension reported on a specialized formula that supports adenosine monophosphate-activated protein kinase (AMPK) activation. Studies show increased AMPK activity helps reduce fat storage, promotes the production of new mitochondria, and helps keep blood glucose and lipids levels in a healthy range. In preclinical models, AMPK upregulation resulted in a 20-to-30% increase in life span.
  • In 2014, Life Extension reported on a groundbreaking product featuring patented nicotinamide riboside (NR), which helps enhance cellular energy metabolism by increasing levels of the coenzyme nicotinamide adenine dinucleotide (NAD+). Studies show that, through the manipulation of multiple critical biochemical pathways, nicotinamide riboside has the potential to improve insulin sensitivity, confer neuroprotective effects, augment the benefits of exercise, and combat the detrimental effects of a high-fat diet.
  • In 2014, a special “ionic” formula that contains zinc acetate, the preferred zinc compound to provide enhanced seasonal immune support, was reported by Life Extension. This product releases 100% of its zinc as positively charged zinc ions. Zinc acetate lozenges have been shown to strongly support immune function.


  • In 2015, Life Extension reported on a formula providing concentrated pollen extracts specifically selected for effective prostate support, healthy urination patterns and prostate function. Two fractions in the flower pollen extracts, a water-soluble and a lipid-soluble fraction, support prostate health by helping maintain smooth muscle tone in the prostate, bladder, and urethra. For the first time, this European extract is available to Americans, providing a more potent dose in a convenient once-daily softgel.
  • The Life Extension Foundation supported a study titled “Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans,” which was the result of collaboration with researchers from Barcelona, Spain. The study, which showed EGCG as a promising therapeutic tool for cognitive enhancement in Down Syndrome, was published in Molecular Nutrition and Food Research.   
  • The Life Extension Foundation supported a study titled “High-Dose Vitamin D3 Supplementation in Children and Young Adults with HIV: A Randomized, Placebo-Controlled Trial,” which was the result of a collaboration with a Children’s Hospital of Philadelphia researcher. The study, which found that 7,000 IU of vitamin D3 improved immunological parameters in HIV-positive individuals, was published in The Pediatric Infectious Disease Journal
  • The Life Extension Foundation co-funded research at the University of Liverpool to sequence the genome of the bowhead whale, a mammal whose nearly 200-year life span makes it the longest-living on earth. In findings published in the journal Cell Reports, the researchers discovered as many as 80 candidate genes related to DNA repair and cell proliferation that may help protect the whale from cancer or contribute to its inordinate longevity.
  • In 2015, Life Extension highlighted the ancillary benefits of the angiotensin II receptor blocker medication telmisartan. Research has revealed that telmisartan, aside from effectively and safely lowering blood pressure, improves insulin sensitivity and endothelial function, enhances mitochondrial activity, and, in preclinical trials, helps control body weight.
  • In 2015, Life Extension shed light on the lethal consequences of CoQ10 censorship by the FDA which has resulted in more American deaths than all the major wars combined. A recent study powerfully supported the use of CoQ10 for sufferers of congestive heart failure who combined the nutrient with standard therapy, achieving a 44% reduction in cardiovascular mortality compared to those receiving standard therapy alone.
  • In May 2015, Life Extension described the dangers of a common genetic mutation (MTHFR C677T) that contributes to elevated homocysteine in a substantial portion of the population and how an active form of folate — 5-methyltetrahydrofolate — may normalize homocysteine levels in people with this genetic defect.
  • In 2015, Life Extension published meticulous comparison data describing the pros and cons of three newer anticoagulant drugs (Pradaxa®, Elliquis®, Xarelto®) and compared their effects to warfarin (Coumadin®).
  • In 2015, Life Extension described Photodynamic Immunotherapy, a new outpatient therapy for breast cancer patients that provides a nontoxic alternative, allowing them to avoid surgery, radiation, and chemotherapy.
  • In 2015, Life Extension introduced an oral formula that targets dry eyes from the inside out for systemic continuous comfort.
  • In 2015, Life Extension introduced a new approach  to activate endothelial production of nitric oxide, which signals the smooth muscles to relax, inducing vasodilation to support healthy circulation. Clinical research showed an 18% improvement in flow mediated dilation, a direct marker of endothelial function.
  • In 2015, a Life Extension funded study showed that melatonin reduced DNA instability from "jumping genes," reducing the risk of cancer and aging-associated diseases — apparently by a mechanism independent of melatonin's antioxidant effects.
  • In 2015, a Stanford University School of Medicine study partly funded by Life Extension developed a method to assay gene expression in individual cells, as a step toward reducing aging of stem cells.
  • In 2015, a Life Extension funded company developed compounds that restored blood flow in rats following two hours without blood flow, as a possible treatment for stroke in humans.
  • Life Extension Clinical Research, Inc. (LECR) completed two clinical trials presented as posters at the March 2015 Experimental Biology conference in Boston, MA.
    • The first second poster described a study in which a lipid-based formulation containing 5,000 IU vitamin D3 raised vitamin D blood levels 29% over 60 days. From baseline to day 30, mean serum 25-hydroxyvitamin D levels increased by 7.34 ng/mL; by day 60, the increase had risen to 13.1 ng/mL. These results were statistically significant when compared to the use of a powder-based formulation.
    • The second poster presented a case series on the effect of bisphosphonate medication use on CoQ10 blood levels.
  • In 2015, Life Extension coordinated the initial steps of the first clinical study to reverse aging in frail elderly humans by utilizing plasma youth factors derived from stem-cell mobilized young human donors.
  • In 2015, Life Extension published a series of articles that supported the benefits of properly prescribed testosterone, offering a compelling rebuttal to a new FDA mandate requiring testosterone labels to warn that the drug may increase risk of stroke and heart attack.
  • In 2015, Life Extension explained why it is critical for ischemic stroke patients to be rapidly treated at a comprehensive stroke center and receive advanced treatments  to remove blood clots before permanent paralysis/death ensues. Life Extension provided a list of comprehensive stroke centers across the United States.
  • In 2015, to help consumers achieve the maximum reduction in advanced glycation end products (AGEs), Life Extension published the number of AGEs per serving of over 500 different foods and drinks.
  • In 2015, Life Extension reported that up to one-third of the 72 million CT scans performed in the United States annually are not only unnecessary but dangerous and that these CT scans led to the occurrence of 29,000 new cancer cases in 2007.
  • Life Extension reported on a 2015 discussion in the research community about initiating a human study of metformin's anti-aging properties, which Life Extension readers have known about since 1995. The FDA has since approved a large-scale human study to test metformin's longevity-enhancing benefits.
  • Life Extension reported in 2015 on a multistep process to provide the highest-quality Alaskan omega-3 fish oil products that reduce oxidation measurements more than five-fold and have earned a Five-Star Rating from the International Fish Oil Standards (IFOS™) Program for purity.
  • In 2015, Life Extension introduced a novel standardized wild green oat extract that has been shown to inhibit the enzyme monoamine oxidase-B (MAO-B), promoting healthy dopamine levels for more youthful cognitive health and performance.


  • Life Extension funding to 21st Century Medicine, Inc., has allowed that company to establish low-temperature banking of corneas (for blindness) and pancreatic islets (for type 1 diabetes).
  • Life Extension funding to Tulane Medical School researcher Dr. Victoria Belancio led to a patent application for an antibody against "jumping genes," which have activity that can lead to cancer and aging.
  • Life Extension shed light once again on the price-gouging scandal behind generic drug costs that leave millions of Americans without access to affordable medications. A solution that could reduce generic drug costs by 90% was proposed.
  • At the April 2016 Experimental Biology conference in San Diego, California, Life Extension Clinical Research, Inc., presented results of a study that tested perispinal etanercept (Enbrel®) along with ancillary inflammation-suppressing therapies in the management of mild-to-moderate Alzheimer's disease.
  • Life Extension funded a super-centenarian project that provided valuable data for Harvard researcher Dr. George Church in his quest to reverse human aging.
  • Life Extension and others partnered to launch Age Reversal Therapeutics, Inc., a company aimed at funding groundbreaking age-reversal research.
  • Life Extension co-sponsored the Revolution Against Aging and Death Festival (RAADfest), billed as the world’s largest gathering of longevity enthusiasts. The three-day conference, devoted to increasing the availability of age-reversal technologies, featured presentations by 40 prominent scientists and activists, including Aubrey de Grey, Ray Kurzweil, and Suzanne Somers.
  • Life Extension and Insilico Medicine, Inc., announced an exclusive collaborative effort to identify novel biomarkers of human aging through the use of big data analytics and artificial intelligence, with the ultimate goal of nutrient formulation discovery to support health and longevity. This partnership led to the publication of a research paper describing applications of the human signaling pathway-centric GeroScope platform for scoring human tissue-specific geroprotective properties of compounds implicated in the aging of model organisms.
  • A team of researchers at the University of Rochester in New York that received funding from Life Extension found a chemical means of controlling DNA repair, a crucial process in healthy aging protocols and cancer treatment.
  • A team at the University of Southern California that was funded by Life Extension won an award for near-perfect preservation of brain tissue by a combination of aldehyde and cryopreservation.
  • Life Extension Clinical Research, Inc., assisted researchers from the University of Miami on a Life Extension-sponsored clinical trial involving treatment-resistant depression. Findings were published in 2016 in the peer-reviewed journal Psychiatry and Clinical Neurosciences.
  • Life Extension Clinical Research, Inc., supported researchers from the City of Hope in securing study products for a clinical trial that was sponsored by Life Extension and involved patients with pancreatic cancer.
  • Life Extension introduced a unique formulation containing two scientifically studied ingredients that provide long-term support for the lining of the stomach and promote a healthy stomach environment.
  • Life Extension introduced a supplement formula that naturally supports the aging brain, by promoting youthful cognition through a healthy response to sugar in brain cells and by modulating the levels of amyloid beta and tau proteins in the brain.
  • Life Extension exposed flaws in the studies used to rationalize the FDA’s decision to add a black box warning label to prescription testosterone drugs.
  • Life Extension’s quarter-century advocacy of PSA blood screening to detect prostate cancer was reaffirmed by an analysis in the New England Journal of Medicine which discredited the study behind the U.S. Preventive Services Task Force’s 2012 recommendation against PSA blood screening for healthy men.
  • A study funded by Life Extension revealed that improved muscle regeneration in old mice from the sharing of blood between old and young mice was due to blood factors, not youthful organ function. Life Extension intends to initiate a study showing rejuvenation of elderly humans using blood factors from young humans.


  • Collaborating with Insilico Medicine, Inc., Life Extension used deep-learning artificial intelligence to identify ingredients that help turn back the clock at the cellular level. The result: Ageless Cell™ — the first supplement in our breakthrough GEROPROTECT™ line — which helps rejuvenate near-senescent cells and encourages the body’s healthy process for dealing with senescent ones. 
  • Life Extension introduced a supplement featuring beneficial farm fresh ingredients based on the Mediterranean Diet — one of the world’s healthiest eating styles — using an innovative water extract process that yields a pure, potent polyphenol and phytonutrient blend.
  • According to the Surgeon General, deep vein thrombosis may cause up to 180,000 deaths each year, with those who spend the most time sitting at the highest risk. In 2017, Life Extension reported that researchers had developed a nondrug approach for the prevention of deep vein thrombosis, utilizing two natural compounds that drastically reduce platelet aggregation and fibrin-induced clots.
  • Life Extension reported a new study from Johns Hopkins University, which showed that people who use proton pump inhibitor drugs are at increased risk of kidney disease. Further studies revealed that these heartburn drugs could increase risk of bone fractures and heart disease, leading Life Extension to examine natural approaches to relieve heartburn.
  • Life Extension exposed how generic drugs whose active ingredient costs only pennies are sold to desperate consumers for hundreds of dollars. The solution to this price gouging is to remove antiquated regulations that cause drugs to cost far more than they should.
  • Based on new data indicating that blood drawn 2 to 6 hours after a normal meal provides more realistic test results, and noting that blood tested in an artificial “fasting” state may not account for vital disease risk markers specific to an individual, Life Extension recommends against fasting prior to most blood tests. 

Life Extension is growing because people are becoming aware that recommendations published by the Foundation in the early 1980s are now scientifically validated, and many are even accepted by the medical establishment.

Life Extension Scientific Track Record